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mTORC1 regulates cystine uptake through ATF4 Among the 61 shared mTORC1- and ISR-induced ATF4 gene targets identified, the cystine-glutamate antiporter Slc7a11 (xCT) was the most significantly induced gene upon insulin treatment (Figure 1F)

Oxidation of glucose and pyruvate, however, generates ATP by both substrate level and oxidative phosphorylation, generating more ATP per oxygen consumed

Taylor and Francis, Washington, DC, pp 171191 Scown TM, Santos EM, Johnston BD, Gaiser B, Baalousha M, Mitov S, Lead JR, Stone V, Fernandes TF, Jepson M, van Aerle R, Tyler CR (2010) Effects of aqueous exposure to silver nanoparticles of different sizes in rainbow trout

[PubMed 2121027] 1499

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